Siena was founded in 1997 to meet the increasing demand for Catholic education on the Sunshine Coast and is located at Sippy Downs. The College opened with 98 Year 8 students in four streams and the first Senior class graduated in 2001. In 2003, a fifth stream was added to Year 8 and in 2015 Year 7 was added as part of the Flying Start programme for Queensland schools, bringing the maximum enrolment to 920 students. Siena is part of an educational precinct that also includes the dual campus (P-6 and 7-12) of Chancellor State College, the University of the Sunshine Coast (USC) and Siena Catholic Primary School (P-6), which opened in 2002. The College is an Archdiocesan College administered by Brisbane Catholic Education and has close links with the Suncoast / Stella Maris Parish.